Post # 1
After 8 months of NTNP and 10 months of TTC, my husband and I will be seeing a RE next month. We both checked out fine and the only testing I haven’t done is HSG. My husband has healthy SA (172 Million/mL, 75% motile, 7% morphology) and all the bloodwork and sonohystergram came back “normal” for me.
We’re looking into finding more info on IUI. How many of you ladies have tried un-medicated IUI? There are mixed feelings on un-medicated and how it can be a waste of money and time. What about Clomid vs. Femara? Clomid is said to produce more side-effects and increases your chance of conceiving multiples, but has anyone here tried both? And what is the purpose of a trigger shot? I’m sure my Dr. will recommend what’s best for us, but I thought I’d ask the board for experience.
Post # 2
I did an IUI using Femara, so I can’t speak to unmedicated IUIs or what Clomid is like.
I did use a trigger shot, though, so I think I can shed some light on that. My understanding is that Femara helps you ovulate in general, and the trigger shot ensures that you ovulate during a very specific window of time, which helps the doctor time the IUI procedure, which raises your chances of success.
So I took Femara, which helped my ovaroes develop follicles (containing eggs). The RE monitored these follicles closely, and when I had a couple of nice, mature ones, he told me to take the trigger shot, which would casuse the eggs to release within 24-48 hours, I think. We did the IUI 2 mornings in a row, starting the morning after I took the trigger shot. They timed it so that the sperm would be in the uterus immediately before the follicles released the eggs, to increase the chances of conception (I had thought that I should ovulate before they did the IUI, but the sperm lives in the uterus for a few days, so they want the sperm in there before the egg is released).
Anyway, I’m getting carried away with the detail… Good luck to you and your husband!
Post # 3
I am unexplained infertility and have had 5 IUIs, none of them resulted in a BFP. I took clomid for the first 4 to supposedly “boost” ovulation despite not having issues. I was lucky and didn’t really have any of the side effects (hot flashes, headache, dryness, etc) but I was moody and hated DH a time or two!!! My fifth IUI was my first monitored (u/s and bloodwork every other day) I did Puregon and a trigger shot and again was lucky with no significant side effects.
Post # 4
- Wedding: September 2014 - Jacksonville Inn
In the past when I was TTC with my ex partner I underwent 6 IUI’s with Clomid and trigger shot. We used frozen donor sperm, and we changed donors twice. 2 ended in BFP’s that quickly ended in m/c. I have PCOS and endometriosis. I respond well the Clomid so I was on 50 mgs Clomid, 2000 mgs Metformin and then a 10,000 IU HCG trigger shot. I always had 1-2 dominate follicles with a few smaller ones that were not big enough to trigger. I have never taken Femara or done a unmedicated IUI, so I can’t speak to that. I took Clomid on days 3-7 of my cycle and on day 10 would start using OPK’s. I was to call the Dr. when I got a + or on CD 14 if I had not gotten a + yet. Then I would have my ultrasound to check on my lining and follicles, then go home and do my trigger shot. IUI was usually 24 hours later if I was just doing 1 IUI. On the cycles I did 2 IUI’s my protocol was 24 and 48 hours past trigger.
I took my Clomid at night and had very few side effects from it. I had more side effects from the Metformin, but I was on a high dose. I believe the chance of twins is 10% with Clomid and triplets are less than 1%?
Post # 5
NowandLater: Just wanted to pop in and say I’m so glad you started this thread. My DW and I are planning to do IUI using frozen donor sperm, and I’ve noticed there isn’t a ton of chatter on the boards about IUI.
FWIW, several of my friends IRL have undergone IUI: one has a beautiful 6-month-old daughter, one is due in October, one got a BFP but miscarried, and one is still TTC. Three of them definitely used a trigger shot (the fourth didn’t share details with me).
Post # 6
I am pregnant with a singleton via my first IUI. I have PCOS, ovulated very rarely and DH had what our RE called a “borderline” SA. During my IUI cycle, I took metformin, clomid 100mg days 5-9 (I had previously taken clomid during other cycles without metformin and it did not help me to ovulate) had an ovidrel trigger and then IUI 48 hours later. I didn’t have side effects with the clomid and had monitoring throughout the cycle so we knew there was only one dominant follicle. Had there been multiple, we would have considered canceling the cycle.
ETA: Just wanted to add that I wish you and your husband the best of luck!
Post # 7
stillme: lonsk: Irish2014: LittleRiver: BOGB: Wow, ladies. Thank you so much for sharing. Thank you for opening up and sharing your experience. Those of you with happy ending, congratulations. I bet every doctor visit, needle, pill was worth it. I’ll share about my experience once I visit my RE and have a treatment plan set in stone. Thank you for the well wishes, it means the world to me.
Post # 8
- Wedding: April 2013 - Rhode Island
Good luck NowandLater:! I’ve been watching your FF chart and thinking about you. I hope your appointment goes well.
Post # 9
NowandLater: I might have to refer back to this thread later if we cannot conceive naturally in the next 5 months. I don’t know if we are going to start right away with IUI or wait a bit longer, but definitely something we are considering in the near future.
Post # 10
I was diagnosed with unexplained infertility, my DH had fine sperm. I did 1 month of clomid, a trigger shot, and an IUI. I produced one egg that month and I did not get pregnant. The next month, dr switched me to femara. I produced 2 eggs that month, had the trigger shot, and just had sex instead of an IUI – twins! I had a lot less symptoms with femara than with clomid. Clomid made my ovaries hurt. i wouldn’t waste time doing an IUI unless you have a trigger shot. I hope you get pregnant soon!
Post # 11
Christy42213: Thanks for the kind message, though we may be strangers it’s so heartwarming to have you wish me good luck.
candy11: I hope you never have to resort to fertility treatment. I hope you get your wish within the next 5 months!
razzzzzz: This is so so awesome to hear. I wonder if DRs tend to start w/ Clomid and then move onto Femara. Congratulations on your twins! Do you know the gender of your babies?
Post # 12
NowandLater: yup, boy and girl! They are 8 weeks old now. Healthy and happy little sweathearts
Post # 13
UPDATE: My husband and I wanted to try two more times naturally. BFN both months. I have been officially announced as “unexplained infertility”. These words seem so ironic to me. After tests after tests, there’s nothing wrong with us and we shouldn’t “theoretically” have any problems. But 18 months of not preventing & trying, something’s not right…
So I mustered enough courage to talk to my doctor about our next steps and I’m now scheduled for an HSG and Clomid w/ mid-cycle ultrasound. If this doesn’t work, next step is to do Clomid, ultrasound and IUI w/ trigger shot. Come what may, right?
Post # 14
We have been trying for a year –
My FSH and AMH tests were normal as were my thyroid. My ultrasound was also normal. DH’s sperm was considered normal as well.
My OB referred me to a specialist who she recommends for IUI, but I just found out that doctor doesn’t take my insurance. I now have to wait for my OB to call me back (she’s not in the office until next Monday).
My period’s due on Saturday or Sunday, but I’m not hopeful.