Zofran and Birth Defects

posted 2 years ago in Pregnancy
Post # 4
8389 posts
Bumble Beekeeper
  • Wedding: April 2013

banana330:  Honestly, I think if someone is pregnant, their best bet is to avoid all medications, caffine, tylenol, GMOs, etc. if possible.  All substances and medications carry some sort of risk it seems.

Post # 5
992 posts
Busy bee
  • Wedding: January 2010

Took Zofran all through my pregnancy, had an perfectly healthy baby.

Talk to your Dr. Do your own research and draw your own conclusions. 

Post # 6
2179 posts
Buzzing bee
  • Wedding: March 2024

I’m with ExcitedScaredBee, every woman needs to talk to their Dr about the risks of medications taken while pregnant.

Also in a perfect world women wouldn’t have to take medications while pregnant, but for those of us who are pregnant and have been pregnant we know that sometimes medication is the only way to fix certain issues we are having.

Post # 7
516 posts
Busy bee
  • Wedding: September 2013

Meh I am drinking my morning coffee (less than the daily limit I may add), I have eaten at subway (bad deli meats) am on my anti anxiety in low dose (would rather function then be in a ball) and am on the canadian form of anti nausient diclectin and it has given me my life back.

If someone wants to be a matyr and say no to everything for the sake of the fetus just “in case” well that is their call. My theory is that we can always be overly cautious and something can still happen, I follow the study guideline, listen to my doctor and midwife and abide by the science available and stay within those limits. That is my call to make and I am very happy with it.

Post # 8
1040 posts
Bumble bee
  • Wedding: July 2014

If possible it is best to avoid medications during pregnancy if possible. But it’s not always possible – and hyperemesis gravidarum can be life threatening for both mother and child in severe cases.


I think it’s also important to point out that this is not a study. This article has absolutely no proof that these birth defects are caused by ondansetron. What has happened here is that women who took ondansetron during pregnancy had certain complications which their doctors suspected could be due to ondansetron (but it’s impossible for them to prove it). The doctors reported the possible side effects to the safety authority (standard procedure with a suspected drug adverse reaction). This article makes no mention of what the overall rate of birth complications in women taking ondansetron is, or how it compares to the general population. 



Im not saying that ondansetron is safe. But from a scientific point of view this article is incredibly flawed, to the point where it could be considered scaremongering. If you have concerns about ondansetron, I would suggest researching the medical literature looking for large scale studies and meta-analyses (a double blind randomised control trial comparing ondansetron to placebo would be best, but tricky to do in pregnancy). Don’t take your facts from journalists with no medical training. 

Post # 9
2502 posts
Sugar bee
  • Wedding: October 2011

missjewels:  I totally agree. There is something about the “but why risk it!??!” attitude that bothers me. Many “risky” things clearly have a benefit that makes them worth it, IMO. I skied all winter while pregnant (for my job). If I had had to quit my job in November at only 6 weeks pregnant I would’ve been very lonely, bored, and depressed. That just wasn’t worth it, to me, although I’m sure some people judged me for doing something “risky.” I think the benefit of taking Zofran, to women with hyperemesis gravidarium or even just very bad morning sickness, clearly has a benefit that outweighs the risk, although of course it is a personal choice to be made along with a doctor’s reccomendation.

Post # 10
1448 posts
Bumble bee
  • Wedding: January 2012

My take as a research biologist….There are studies that show women who are extremely sick during pregnancy are more likely to have birth defects. They can’t keep things down(folic acid) or there was already something genetically wrong( studies show some chromosomal defects cause higher levels of hcg which makes women sicker). I don’t find it hard to believe that these women also are more likely to take zofran. Therefore more women on this drug end up with complications. So unless there are true scientific studies done that rule out other factors I’m going to say its a correlation not causation. 

I took zofran and have a perfectly healthy girl. 


Post # 11
483 posts
Helper bee
  • Wedding: May 2018

with the culture of guilt among western pregnant women i doubt there would be too many women jumping straight to Zofran. I believe it is always used as a last resort by people who are desperate to feel better, to be able to function.







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