Am I out of line to modify my prescribed letrozole dose?

posted 2 years ago in TTC
Post # 2
4060 posts
Honey bee
  • Wedding: August 2012

I mean…your fertility Drs are Drs in fertility for a reason. Because they spent a lot more time learning about all this than a bunch of women on a TTC board. Personally I would go by what they recommend.

Post # 3
2420 posts
Buzzing bee
  • Wedding: April 2014

MsTrulove22 :  I would trust your doctors decision to cut the dose down and NOT modify it by only taking half of what has been prescribed. While I understand your concern for overstimming, your dose is already now 1/2 of what it was last cycle, so the odds of overstimming are much much less this time around. I’ve taken my fair share of letrozole, and honestly, a dose that is any less than 2.5 might not be effective – so cutting down could potentially cause you to begin producing estrogen (which letrozole should stop your body from producing until you’re done with your pills) and potentially ovulate sooner than expected. Of course you don’t want to have another cancelled cycle/delay in TTC, but also there is a purpose for each dose and if your RE was concerned – they would have given you a different protocol.

Post # 4
253 posts
Helper bee
  • Wedding: October 2019 - .

If you don’t like what your doctor is saying, find another doctor. 

Post # 6
14949 posts
Honey Beekeeper
  • Wedding: June 2011

the diff between 2.5 and 5 mg is pretty big.  I ovulate on my own, albeit very late, and I didn’t respond to 2.5 (still ovulated around the same time as normal around day 28)…. but I did respond to 5mg and ovulated around day 17 with only 1 follicle.  I would not go chopping pills in half.

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