Post # 1
So this is the plan for this cycle- didn’t respond to clomid, moved on to femara (8 days x 5mg) and produced 1 lowly follicle and a failed IUI. I am not a candidate for injectables (Amh is extremely high and the RE says I would be oversimulated). So 100 mg clomid and 5 mg femara days 3-7 followed by IUI is the game plan. Has anyone had experience with this combo? I really can’t find anything online, outside of the same question posted on a few message boards with no real beneficial responses (mostly “I wouldn’t touch that combo with a 10 foot pole”, “I hope you’re seeing an RE”, “that makes no sense” etc). I could use some reassurance, optimism, or general knowledgeable feedback, as all I can think about is the horrible side effects from both.
Post # 2
I’ve never heard about it but I’d trust the RE over absolutely anything you find on the internet once you’re on any sort of cocktail. Drug interactions are really hard to predict and require a lot of expertise–generally you really want to just talk to either your pharmacist or your RE, who is specifically trained in both reproductive hormones and the uses and effects of these specific drugs, about any questions relating to that.
Give a call to your RE (or if yours is like mine, your nurse who will then ask your RE) and ask about the side effects etc.. its a totally legit question!
Post # 3
I’m honestly not that concerned with side effects, more so dreading them as both drugs really affected me during the last 2 cycles (bloating, bleeding, sweating, mood swings, etc). I’m really am curious if other women responded will to this combo, success stories, etc. They are so nice to read and really do wonders in keeping the spirits high. I just unfortunately cannot find much at all!
Post # 4
Honestly, I’d take my chances with injectables with careful monitoring if you didn’t respond to femara. Clomid thins the lining so taking that at all would be my last choice. If your doctor tailors your doses for injectables, I see no reason why high amh automatically means you are not a candidate for injectables and I’d really question your RE on that point. What happens if you move onto IVF? That is exactly the meds they use for IVF. You can always cancel if you over respond but given your lack of response to femara, I don’t see any benefit to a clomid/femara combo.
Post # 5
I agree with littleanchor
If you only stimmed one follicle on femara, I would think it would be fairly safe for you to go on injectibles. You need a little more of a boost than those meds are giving you and the side effects aren’t great (thin lining etc). I would ask your RE to reevaluate.
FYI, I have a high AMH and PCOS and stimmed perfectly on my IVF cycle. I had about 35 follicles at the start and we ended up with 16 eggs, 12 of which were mature so lots of my follicles stopped growing/didn’t produce an egg even though my AMH is incredibly high.
Is your doctor worried about multiples by “overstimming” or OHSS?