(Closed) Experiences with metformin?

posted 5 years ago in TTC
Post # 2
Member
510 posts
Busy bee
  • Wedding: May 2016

I take metformin for my diabetes, it stimulates your body to make more insulin, I didn’t know it could.be used other ways. It messes with your blood sugar, your moods and some people have really really bad side effects with it, stomach cramps, sweating episodes, vomiting, especially diarrhoea. It can also cause seizures, and collapsing/fainting episodes becausen lowers the glucose in your blood, It can cause stomach upset really easy. My goal set for me by drs is to get my diabetes under control and using diet only to treat it so I don’t have to take this horrible drug for the wedding or TTC. I don’t think this would be a safe drug to conceive on, but I’m not a dr.

Post # 3
Member
1663 posts
Bumble bee
  • Wedding: September 2012

I have PCOS and take Metformin. I have been taking it for 10+years and have had no problems. It helps regulate your period and it does help with ovulation. The only side effect I’ve had is upset stomach once in a while. It also helps to regulate my weight.

When I was pregnant (see, it works!) and nursing I stopped taking it and gained a bunch of weight, but since I’m done nursing I back on it and it’s slowly helping me lose weight and get my cycles back on track. 

Post # 4
Member
249 posts
Helper bee
  • Wedding: Bar Harbor Inn

Metformin has been wonderful for my pcos. I’m really surprised by pp comments. The medicationdidn’t really have many negativeswhen i researched it. It regulated me right away. I didn’t have the acne issues. You will need some time to adjust to the medication. It will cause stomach upset (diarrhea) for about three weeks. Might want to ask about Aldactone fir the acne issues. 

Post # 5
Member
1219 posts
Bumble bee
  • Wedding: August 2013

How strange, I just logged on to the TTC boards to ask the exact same question! I started taking Metformin a month ago for PCOS. I’ve tried several different pills which helped but gave me migraines so I stopped them and used a Nuvaring which was great until we wanted to TTC.

So far so good with the Metformin. I haven’t have any side effects yet. My Doc put me on a wheat and dairy free diet and I am taking Duphaston to help regulate my periods at the same time. My Darling Husband has been working away for the last 2 months so can’t comment on the pregnancy part yet, but am hoping it will happen soon!

 

Good luck!

Post # 6
Member
394 posts
Helper bee
  • Wedding: July 2014

Rabbit56:  sorry, Metformin does work to regulate your blood sugar but it does not increase insulin secretion in your body. 

OP I thinj you’d be best speaking to your doctor about whether this would be the right choice for you. 

Post # 7
Member
2902 posts
Sugar bee
  • Wedding: June 2013

I absolutely think Metformin is why I was able to conceive relatively quickly with PCOS. (One cycle the first try,which ended in miscarriage – not because of the PCOS – and five cycles the second try.) When I was diagnosed with PCOS in my early twenties, I had a period maybe two or three times a year. I got diagnosed, went on birth control pills and then in my early thirties, a year before TTC, added Metformin to the regimen. When I stopped taking BCP, my cycles were textbook 28 day cycles with ovulation on day 14. 

I didn’t lose much weight on it, and it didn’t do much to clear up my skin. (Spirinolactone was great for my acne, but you can’t take it while TTC or pregnant.) And it does have some nasty GI side effects while you’re getting used to it. But I think it’s fantastic. If your doctor suggests it, I’d go for it. Good luck!

Post # 8
Member
347 posts
Helper bee
  • Wedding: April 2013

1) Please consult with your doctor – clearly we all have different reactions and issues with medication. 

2) My two cents: I was diagnosed with mild PCOS, and take 500mg of Metformin. It’s the minimum dosage, and it does work to give me shorter cycles. It doesn’t give me bad side effects unless I go up to 1000mg. However, some people take 2000mg and they’re okay. 

It is safe to take while TTC, and in women with PCOS may help prevent miscarriage up into the first trimester. After that, doctors will wean you off. 

Diet and exercise play a large part in this as well. You can’t just take Met and sit around eating cheesecake all day. It is recommended to cut back on sugar, and anything that converts to sugar, like certain carbs and alcohol. 

Post # 10
Member
1828 posts
Buzzing bee
  • Wedding: November 2014

Tphan:  Thank you for saying that…I about had a heart attack there…

Metformin’s exact mechanism of action is still largely unknown. It works in the liver, decreasing how much glucose your liver is putting out to the rest of the body. It also decreases how well your intestines absorb glucose from your food, and and improves insulin sensitivity (insulin resistance can contribute a great deal to fertility problems, especially with PCOS) by making your muscles and tissues take up the glucose from the blood better.

Because of the way it works, GI problems like nausea and diarrhea are the largest side effects, but they decrease with time. It has virtually NO incidence of hypoglycemia (low blood sugar, where you risk dizziness, etc) because it does NOT affect insulin at all. It is a pregnancy category “B”, which means that animal studies have not shown harm to the fetus, and there are no studies on pregnant women (which is common – it is largely unethical to study pregnant women!). B is very safe, in other words, and metformin has been used in pregnancy for a very long time. As long as your kidney function is good, you should not suffer serious side effects from it beyond the GI stuff.

Talk to your doctor and pharmacist to decide what is right for you.

Post # 11
Member
2902 posts
Sugar bee
  • Wedding: June 2013

hogoboom2012:  I took it through the first trimester, and I’m planning on going back on it after pregnancy. I don’t know if there’s any specific reason to discontinue it during the second/third trimesters – my doctor just said there was some evidence that staying on through the first tri decreased the risk of miscarriage in women with PCOS, so that’s what we did. 

Post # 12
Member
4505 posts
Honey bee
  • Wedding: September 2010

Please just ask your doctor. There is some misinformation on this thread. Only your doctor will know what is right for you — metformin obviously is not right for everyone. 

Here’s my story anyway, even though it may have no relation to your story at all. 

I have PCOS and have always been thin, even skinny. When I was TTC, the RE (after lots of tests!) put me on 1500 mg of metformin/day. I have read that metformin is more successful for TTC in non-obese women, but this may not reflect thel atest research. After being put on metformin, I conceived on my first try, after over a year of trying. I had some diarrhea at first but then my body got used to the drug. 

Anyway — just ask your doctor. Our experiences may be totally different from yours. Good luck!

 

 

Post # 13
Member
398 posts
Helper bee
  • Wedding: December 2014 - Norton Country Club

Secondhand experience here, but it might be helpful… both of my sisters have PCOS (and I do too) and have each been put on Metformin for insulin resistance.  They also happen to have issues with fatty livers, so I thought that might be useful information.  Each of them had very strong nausea and stomach cramps when they first took it. For reference, we are all plus-sized gals if that is relevant to you at all.   

The results with their fertility issues was totally mixed. The sister with the “milder” PCOS symptoms has not yet been able to conceive and has been on it for 3+ years.  Our sister with the most severe PCOS symptoms conceived at about week 8 (hard to tell exact date since baby came early, but was healthy).  Her doctors disagreed (within the practice) about how to handle her medication once they learned she was pregnant- one insisted she stay on, one thought she should be weaned off, one thought she should quit all of it immediately.  She wound up going off of it completely and stayed off until she was no longer nursing.  She mentioned issues with not being able to lose the baby weight to her doctor around 1 year after the baby was born.  Her doctor put her back on Metformin and she began to lose a little weight, then got pregnant again at week 9 of use. 

I do agree with stillme though- your doctor is the best person to ask! 

Post # 14
Member
510 posts
Busy bee
  • Wedding: May 2016

Tphan:  Im not claiming to be an expert, that’s what my endocrinologist told me before presribing it for me. If others have had success, that’s great. It may be used in different doses for this particular issue. My experience for me it’s a horrible drug.

Post # 15
Member
388 posts
Helper bee
  • Wedding: September 2012

I take metformin and I think it played a big role in me getting pregnant.  I was up to 2000 mg when I got my sticky BFP – not gonna lie, the side effects of 2000 mg sucked.  My body tolerated up to 1000 mg without too many issues but it also didn’t respond as well as my RE wanted.  At 1500 mg, my periods stabilized and I got pregnant shortly after while on 2000 mg.  I never really adjusted to the GI issues on the higher doses so once I got pregnant, my doctor dropped me back to 1000 mg (Met-induced GI issues plus morning sickness made for a very unhappy me) and I’ll stay on that my entire pregnancy.  If/when you talk to your doctor about met, ask for the extended release tabs – they’re easier on the stomach and some people don’t get many GI side effects on them.  For me, I still had to watch my carbs really carefully but it was worth it when I could see my periods getting shorter and the weight that I had been struggling to lose just start to drop off of me – which both were great things to help me get and stay pregnant.

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