(Closed) Full of questions today. What is involved in FET?

posted 5 years ago in TTC
Post # 2
12326 posts
Sugar Beekeeper
  • Wedding: June 2011

You can do a natural FET or a medicated FET.  I think most times its medicated cause it’s easier to time and control.  Natural is just that, you track your cycle assuming you have one, and do the LH tests and maybe temp.  5 days after your surge/ovulation, you go in for FET.  Medicated has several protocols.  Mine has been oral Estrace for about 14 days or until the lining is thick enough, then progesterone and 5 days later, transfer.

Post # 4
1365 posts
Bumble bee

I’m starting my first FET next cycle. Mine will be medicated. I’ll take Estrace from CD1 to CD10. If everything looks good on u/s and b/w I’ll add Endometrin. I will take those and then my transfer will be around Day 19ish I believe (I had day 5 blastocyst). I continue my meds till beta and then reevaluate depending on what happens (continue or stop meds). Good luck, friend! 🙂

Post # 5
2176 posts
Buzzing bee
  • Wedding: April 2014

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Prettysmile40 :  As PP said, you can have a controlled or natural FET cycle. Most RE that I know of/have researched prefer the medically controlled because there is less guess work around O time and transfer date, and less constant monitoring than what is needed with a natural cycle.

My first FET protocol was as follows: 2 weeks of estradoil suppositories (2mg 3x/day) and vivelle dot estrogen patches (3 patches changed EOD). I went in for a lining check 14 days after my baseline and was found that my lining had not grown near what they wanted, so I added del-estrogen IM injections 3 times/week. I went in for a second lining check which my RE said my lining was thick enough (only 6.7mm) and that I was cleared to add in progesterone for 5 days before transfer. We had to change our FET date due to my lack of response to meds and since we had a few extra days I opted to have a 3rd lining check, which showed basically the same measurments. We decided to do the transfer at the advice of my RE. I took low dose steroids and an antibiotic for the 5 days prior to our transfer as well. It was unsuccessful.

My second FET protocol will be as follows, to hopefully increase blood flow to my uterus and thicken my lining: A small procedure known as an endometerial scratch done at my baseline after I stop BCP -this will help to recruit NK cells and WBC to repair damage to my endometiral lining. Del-estrogen injections only (no suppositories or patches) combined with baby asprin, trental (a prescription blood thinner), vaginal viagra, 1000iu of vitamin E, L-arginine and a few other supplements. This time, we are scheduling a transfer with the expectation that it will likely get pushed back another week or two – in case I don’t respond well and need more time to grow a lining. I fully anticipate side effects to be terrible and for things to not go as planned.

I’m have pretty severe DOR so I’m not the “normal” protocol or patient and have consistently needed adaptations to be made to protocols that most women will respond just fine to. There really is no way of knowing until you get started, so I wanted to provide an example of what happens if things don’t go as planned. I had a very bad reaction to the high doses of estrogen (even though my lining wasn’t growing) and was sick for the majority of the time on it until adding progesterone, which helped to balance the hormones a bit. Our first FET I was on estrogen for twice as long as I anticipated (about 30 days).

As far as the actual transfer itself, I had to show up with a full bladder and was given a valium prior to going back to the OR for transfer. That part was super easy – similar to an IUI where they use a catheter and insert through your cervix as a way to get the embryo into your uterus. Did you have a mock embryo transfer done? I would be surprised if you didn’t. It’s basically like that, but you get to see via ultrasound the embryo being transferred in, which was pretty cool.

Post # 8
2176 posts
Buzzing bee
  • Wedding: April 2014

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Prettysmile40 :  It’s possible that you had it done at the same time as another procedure (did you have a saline sono or HSG recently?). It’s actually quite important to do as they take measurements from the end of your cervix to the optimal point in your lining for transfer. If you go to high, it can increase chances of ectopic.

If you are having a fresh transfer, it’s likely that your protocol for meds after retrieval will be similar to that of a FET: add in progesterone (either IM injections or suppositories), a steriod and antibiotic. My clinic does not do a day 3 transfer and I’ve never had a fresh, so I’m not sure how it works on the screen. The lining is somewhat easier to see on the screen, it looks like a feather. I’m sure if you ask them they will point it out – my husband was with me for the transfer of course and they showed him what we were looking at (since I’ve seen it a million times, I knew what everything was). He was impressed!

Post # 10
753 posts
Busy bee
  • Wedding: May 2013

My FET protocol was: 

2 weeks of BCP, then started oral estrace 3 days after stopping BCPs. Continued estrace until lining looked good, which was 12 days, then started PIO injections. 5 days later, transfer. PIO is no fun, but otherwise a FET is a heck of a lot easier than a stim cycle.

Post # 12
9309 posts
Buzzing Beekeeper

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Prettysmile40 :  PIO shots are really not that bad – I’ve been doing them for a week now. Tuck the vial in your bra to warm up and thin the oil for about 15 minutes before the shot, hold the skin nice and taut before injection, and add a massage a heat pack for the couple minutes after. The needle is the same as the one trigger shot which you’ll see is scarier looking than it feels. I actually had a lot of soreness the day after my trigger but haven’t had any with the PIO yet!

Post # 13
199 posts
Blushing bee
  • Wedding: November 2012

I started 10 units of Lupron on 10/26 once bloodwork and HSG confirmed ovulation.  I stay on that until I get my “Lupron period” which should be around 11/6 or 11/7.  After that, I will use estradiol and then PIO to prepare for a 12/2 or 12/9 transfer (depending on how my lining is)  

To piggyback on PP, PIO injections are not that bad!  Don’t stress!

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