It sounds like you would be a short drive to Niagara Falls. Sadly the US side isn’t the most exciting, but if you have passports, I would suggest crossing the bridge into Canada. There is lots to do there. The basic maid of the mist, cave of the winds, ect.. There is the skylon restaurant that rotates, for a gorgeous view of the city, the skywheel, two casinos, a really fun bar/bowling alley/restaurant/ arcade place, and all the silly touristy stuff. Last time we were there we bought a Groupon for a beer, wine, and cider tasting, and we got on a coach bus and went all over doing tastings for a day.
If you like to bike, I know a few people that have biked the Erie canal from Syracuse to Rochester. If you get off in Pittsford you can find hotels and some great restaurants. You can take a boat back, so you don’t have to do a round-trip ride.
Watkins Glen at Seneca Lake NY is gorgeous. The hike is very novice, but worth it. You can do wine tastings around the lake, canoe, rent a boat, or just enjoy the scenery. Its a honeymoon, so if you go, you have to stay at Bellhurst Castle (in the castle, not their hotel).
Mt Gretna is a cute area in PA. It’s a very relaxing little cottage spot. Not a ton to do, but enjoy peace and quiet. It’s about 30 minutes to Hershey, and there you can go to Hershey Park, or go to the Hershey museum.. and do a chocolate tasting!
Philadelphia would also be close to a 5/6 hour drive. There is so much to do there. I recommend a night city walking tour. They are so much fun!
You are also close to the Poconos. The Delaware water gap area is beautiful. We have been to Bushkill Falls several times. They call it the Niagara Falls of PA. Not really comparable other than being water falls, but beautiful in its own right. Another very simple hike. I think the whole thing is 4 miles, but there are 4 different routes you can take, with each varying in length, so you don’t have to take the longest one. The park is right outside a small city area, so lots of places to eat. You can also go zip lining nearby, and there is also white water rafting.