IVF Advice Needed

posted 3 weeks ago in TTC
  • poll: What would you advise?
    Stop here - another round isn't necessary : (0 votes)
    Do the 3rd round - it's worth the $$ to have the "insurance" : (7 votes)
    100 %
  • Post # 2
    Member
    150 posts
    Blushing bee
    • Wedding: April 2016

    This is a tough decision as there are so many variables. I am by no means an IVF expert, but I also did IVF with PGS. Is there a reason they didn’t freeze them at the blastocyst stage? Mine were frozen as blasts so we knew how many we had for PGS testing. I had my retrieval at age 33 and they retrieved 13 mature eggs, 10 fertilized (not ICSI) and 7 made it to blastocyst. Of those 7, 5 were genetically normal. Our first FET was a missed miscarriage and our next FET resulted in my 12 week old son. We have 3 more frozen embryos that we hope to have one more child with. If egg quality is a concern and you are ok knowing that you could possibly have several embryos left over and need to decide what to do with them, I think if I were in your shoes, I would go for the 3rd round. Better safe than sorry. 

    Post # 3
    Member
    7131 posts
    Busy Beekeeper

    summerlove23 :  is there a reason they froze so early? My clinic waited until day 5 to see how many made it to blast and then froze so we weeded out the duds early. 

    I would weigh how you’d feel about running out vs. having too many to decide on round 3. I’m biased because I did IVF w/ ICSI and we did a fresh transfer that resulted in our daughter. We got really lucky, but I know I’ll have a little guilt if we get lucky on the first shot again and don’t use all our frozen embryos (we’re going for a FET this summer) even though we’ll donate them to research. 

    Post # 5
    Member
    2090 posts
    Buzzing bee
    • Wedding: August 2014

    I would absolutely keep going. Even with your age on your side, 14 is not that many and assuming 50% make it to blast is by no means a guarantee or fixed number.  I’ve retrieved 37 eggs and only had 9 make it to blast. Plus, if you have male factor, poor quality sperm cannot be fixed with ICSI – it can contribute to the embryo arresting between days 3 and 5. I don’t see a lot of downsides to a 3rd round unless you have a moral opposition to having extra embryos 

    Post # 6
    Member
    802 posts
    Busy bee

    I’ve never heard of an office freezing so early. My Day 5’s were biopsied and PGS tested in both rounds where the embryos had good grading on Day 5. (Our failed IVF turned into a fresh transfer “Hail Mary”) 

     

    Honestly, so many crazy things can happen that unless you can find enough other bees with the same protocol you’re doing to give you advice, I recommend listening to your RE.

     

    In my opinion 14 Day 2’s is probably not enough if you want more than 1 child.  They still have a looong way to go between thawing, growing to Day 5, biopsy, PGS, transfer, implantation, and then hopefully developing normally once in your womb. 

     

     

    Post # 7
    Member
    7131 posts
    Busy Beekeeper

    summerlove23 :  what’s the cost savings? And when do you want to transfer? Those answers would also play into my decision. When I did IVF I was already two years into TTC and I was just ready to get pregnant already. I wouldn’t have been patient enough to wait and do a “just in case” round. That said – my IVF was covered by insurance so cost wasn’t a factor for me. 

    Post # 10
    Member
    1217 posts
    Bumble bee
    • Wedding: October 2016

    The dropoff from fertilization to blastocyst is typically more llike 75%. This is especially true when you have MFI and sperm issues (this is when you tend to see a higher drop off between days 3 and 5). If you want two kids, statistically you’ll want 6 PGS normal blasts. I’d do the third cycle. 

    Post # 11
    Member
    9076 posts
    Buzzing Beekeeper
    • Wedding: October 2013

    you’ve got a lot of embryos!

    i do 2 fresh rounds.  round 1, my progresterone was too high to transfer.  i think i had 7 retreived, 5 fertilized with icsi, 2 were freeze quality.

    round 2, 9 retreived, 5-7 fertilized with icsi (can’t remember), 4 excellent quality.  i transfered, resulted in my son. other 3 frozen.

    FET, 1 transfered from frozen batch #1. resulting in my daughter.

    now i have 4 left and will not be using them.  we didn’t know the transfers were going to be successful on the first time each time.  i wasn’t comfortable with only having 2 frozen and starting transfers, especially since i bought secondary insurance oop to cover IVF and met the OOP max.  so everything i did relating to IVF needed to be completed that year or we wouldn’t have been able to afford it. and it still cost us almost $30k with insurance.

     

    so to me, with 14 embies, you don’t need another fresh round.

     

    I’d also suggest joining the Resolve message board.  Resolve is the national infertility association.  The people are so wonderful and everyone is going through the same thing.

    Post # 12
    Member
    3 posts
    Wannabee

    I’ve never heard of freezing fertilized eggs but based on the fact that the third round will involve defrosting all the fertilized eggs, the cost savings and the hypothesis that egg quality is better today, I’ll say go for another round if your body and mind can sustain it. My experience is not the norm but all my fertilized eggs converted to 5-day blasts and all are PGS normal. 

    Post # 13
    Member
    2130 posts
    Buzzing bee

    Sorry you’re in such a tough spot. I’d personally want to skip the 3rd round and save that money, but honestly, if you feel like your body and finances can handle it, doing that third round gives you some insurance. At this point, you don’t know if you’ll have a normal drop-off or not. I’ve had friends that ended up with as many 5 day embryos as fertilized eggs and friends with 26 fertilized normally and 0 that PGS tested normal. IVF is just this terrible set of unknowns and its even harder when you don’t have a support network that knows what you’re going through and understands the hard and costly decisions you have to make.

    Post # 14
    Member
    3504 posts
    Sugar bee

    I read studies that say 2PN embryos had just as good, or better, pregnancy rates as blasts. I thought that was interesting. Not sure if this is helpful or not, but I recently spoke to my RE about testing our frozen embryos. He said they’ve been studying the effects of thawing, testing, and refreezing embryos and they’ve found that success rates drop 10-15% when you do this. I think 14 sounds like a very good chance that you’d have enough for two kiddos, but without ever having tried a FET and not knowing how many are genetically normal, plus you’ve essentially alread paid for three rounds, I might just go for the third. 

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