Post # 1
So for the past three days I have taken 1cc of Menupor and 300 units of Gonal F. Reading and talking to other bees, I am considered “high” dosage to start out. This kind of surprised me but I went with it. I just went in this morning for my ultra sound and bloodwork. I wont get my bloodwork results until this afternoon but the ultrasound the doctor was very short with me but seemed surprised. I asked if there was something wrong and he said that nothing has changed since he saw me last. I asked what it meant and he said he couldnt answer me since he doesnt have my blood resutls (not sure what that has to do with anything) but my medicine may increase (double potentially) and I will go back in on Friday. That the nurse will call me with all details.
This obviously has me very concerened. I hate, like HATE,the menupor. It hurts so freaking bad going in. Is my body not taking to the medicine? Could this not work for us? Am I doing something wrong?
My question for you is, have you gone through this? What did the doctors do? Were you able to get any eggs? Did you have to stim longer? Did you have to change medicine? Please, any information would be greatly apprecaited.
Post # 2
I have no answers for you, but try not to get too anxious about anything until they call. Maybe your follicles are just being slow to respond. I’m sorry the doc was short with you, but hopefully you’ll get answers tomorrow. FWIW, I expect to be in a similar position tomorrow when i have my first monitoring appointment.
Post # 3
i saved my protocols. and just looked it up. my first round of IVF i did 225 Gonal F, 150 Menopur. i recall the amounts were adjusted through the cycle as they saw the follicle growth, if i was fast or slow to respond.
for IVF#2, i did a different protocol.
they also gave a range for trigger and retrieval because they didn’t know how i would respond.
i doubt you are doing anything wrong. just wait until you talk to the nurse this afternoon. and ask all the questions you want. don’t be shy, your nurse is there for you.
Post # 4
mama2bee71 : There is nothing you have done wrong. The thing with IVF protocols is they are largely based on your AMH/LH/AFC to begin with. Once you start stims and have your first ultrasound/labwork done, they are able to tell if you are responding to the medication and adjust your doses as needed.
I know I mentioned to you before that I was on 450 Gonal and 150 Menopur – my RE said that 600 units of FSH is the highest she would go, due to studies done that say anything above that is ineffective. You have a lot of room to wiggle with still, but I would also wait to see what your estrogen levels come back as. I have pretty terrible DOR, and we got 5 eggs (4 mature/fertilized and 1 embryo) and 6 eggs (5 mature/fertilized and 2 embryos) respectively. I am living proof that all you need is one – our first transfer failed with one of the embryos from our second cycle, but I am literally going in for induction tonight after a healthy, full term pregnancy with our one embryo from cycle 1.
It’s possible you will stim longer than the “average” IVF cycle with your same doses and reassess at your next monitoring, it’s possible they will cancel and start over with a new protocol. The good news is, even if they increasee your menopur, the amount of fluid will likely remain 1cc (just adding an extra vial of powder) so the shot pain will not change. Things are tricky in terms of figuring out what will work best for everyone.
Post # 5
When I asked my RE about Menopur, he said it was the same as using low dose HCG which I was already using and that Menopur is a pre mix of the low dose and FSH. Maybe you can ask about that if Menopur is an issue for you?
Post # 6
pinkshoes : BeverlyGeese : ajillity81 : Whirlwind03 :
Thank you ladies. I just got off the phone with nurse and my estrogen did go up (108) so it shows the meds are working, but I guess slow. So they doubled the menopur. I am doing two full powders. I go back on Thursday for bloodwork and ultrasound to see if that does the trick. Is there a limit on how high you can go on this stuff? I am praying this doesnt add double burn on. Ugh, I hate this stuff!!!! I just hope this works and we get a lot of eggs. Does anyone know what the estrogen does?
Post # 7
Estrogen rises appropriately when your follicles begin to mature/develop. When you have a mature follicle that will release an egg, it generally raises your estrogen levels to between 150-300 per mature follicle. In my stim cycles, my estrogen got above 3,000 but as you can see, it did not equate to that many mature follicles (common with DOR).
The menopur shouldn’t burn any more than it already does, espeically since I assume you are still going to mix the two vials with 1cc of water?
My RE would not let my FSH (from menopur and gonal-f) exceed 600iu each day.
Post # 8
Thank you for that information. I am not writing down the information they are telling me when they call.