(Closed) IVF success with unexplained infertility?

posted 5 years ago in TTC
Post # 2
Member
305 posts
Helper bee
  • Wedding: July 2017

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yellowtulip8:  This did not happen to me but it did happen to my sister. She had the same unexplained infertility. She and her husband tried for two years before they started down the IVF path. I can report that, although it was a terribly emotional and sometimes painful time for them going through the IVF process, they are now pregnant with a little baby boy 🙂 .

Since I personally did not go through the process it is hard for me to answer your other questions. I can only report back what my sister told me. The initial process was easy. She was put on birth control for two weeks to regulate her cycle, then she started the hormone injections to jump start her reproductive system. The shots were hard for her to handle because she does not like needles and she said they burned and the side effects were no fun like extreme bloating and moodiness. She was most afraid of the egg retrieval because she had to go under for the procedure. The procedure went well. At the end of three days they had 7 embryos growing in the lab. They put two of the embryos in on the third day. She had to remain on the hormones at this time which continued to make her bloated and cranky. Then came the scariest part….the TWW. This was the time when her emotions were a mess. Thanksfully, she got her BFP about 8 days after the insertion procedure…it was light and her hubs didn’t believe her yet but it was there! And that line got stronger everyday until she had confirmation from her doctor.

I bet if I asked her now if she would do it all over again she would say yes in a heartbeat. That baby boy is worth the few weeks of bloated discomfort and the shots and the procedures.

Post # 3
Member
1014 posts
Bumble bee
  • Wedding: October 2014

We were in the same (or similar) situation. We were unexplained, did 5 IUI’s with clomid/femara + triggers. Never a BFP. We set up an IVF consult, and the week of our appt I suddenly got a BFP naturally. If I hadn’t, I know we would have gone through with IVF at the two year mark. I had a lot of reservations about it too, but my nurse at the time explained that it can provide a lot of answers for those with unexplained infertility, and can usually identify the problem. 

Because you ovulate naturally, stimulating your ovaries shouldn’t be too difficult, which means less days of injections. I hope you get your BFP really soon! 

Post # 4
Member
733 posts
Busy bee
  • Wedding: October 2014

Commenting to follow.  I also have unexplained infertility (w/ the exception that my CD21 progestone is somewhat low).  I’m currently in the beginning of my 3rd clomid + trigger + IUI cycle (still taking clomid).  If this results in a BFN, I do not want to do any more IUI’s since I have lifetime max insurance coverage for fertility treatments.

Post # 5
Member
677 posts
Busy bee
  • Wedding: June 2014

DH’s cousin and her husband dealt with unexplained infertility. They did IVF and were successful on their first round, freezing the remaining embryos. Their little boy is 18 months and they just did an embryo transfer for baby #2!

Post # 6
Member
1684 posts
Bumble bee
  • Wedding: August 2013 - backyard in the woods

My coworker and I started IVF the same month and are only a year apart in age. Our experiences were vastly different. She/her husband were unexplained and it worked first try- she had a bazillion follicles, made 21 eggs, fertilized 12, ended up with 5 perfect blasts and tada! She has 4 frozen for later too! Turns out that my husband and I have major issues, so it’s not so easy lol. 6 months later and we haven’t even gotten to make an embryo yet:( I found out at pretesting that I have very few eggs left and my husband doesn’t make sperm. If it stays unexplained your chances are likely good. If you find out about other issues during your testing, it could be much harder.

Post # 9
Member
419 posts
Helper bee

We did IVF for unexplained. It scary to leap in to, but it was the best decision I’ve ever made. I had the same thoughts of it being an extreme move considering we couldn’t point to anything that was wrong. We actually skipped over IUIs as well. I have a beautiful baby boy from our first IVF try. Throughout my pregnancy, I had some weird feelings like we somehow cheated, but once he was born, those thoughts never entered my mind. 

By The Way, I know everyone has different experiences, but IVF was easy peasy for me. I had more side effects from clomid cycles than the IVF meds. 

Post # 10
Member
733 posts
Busy bee
  • Wedding: October 2014

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alove2:  Did you do PGS testing on the embryos? Did you have just the 1 transferred?

Post # 11
Member
201 posts
Helper bee
  • Wedding: October 2013

I’m in the same situation. 32/34, TTC for ~15 months, all tests are great so we’re unexplained. I had one chemical pregnancy on our 7th cycle but no pregnancies before or since. We did 3 months on letrozole and 2 on clomid, one with IUI, no luck. We were going to do a few IUIs with injectable meds, but we decided to skip that step and move on to IVF. I totally understand feeling like it’s overkill when they can’t find anything actually wrong. Our consult is scheduled for the beginning of June, but there’s a wait to start the process, which is fine since we’re taking a few months to financially prepare. Good luck to you!

Post # 12
Member
638 posts
Busy bee
  • Wedding: June 2015

Also commenting to follow. We are unexplained as well. We have done Clomid + TI, 2 rounds of Clomid + IUI and a round of Follistim + IUI. Trying to decide when we should be done with IUIs and move on to IVF…

Post # 13
Member
419 posts
Helper bee

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soontobemrs1011:  I had 15 eggs retrieved, but only 7 were mature for some reason. In my first appointment I expressed a little concern about having too many frosties (ha, I wish) so she stimmed me a little more gently than I would have liked. Of the 7, 3 fertilized (ICSI). Because we only had 3, we transfered 2 on Day 3 and one stuck. The 3rd grew to a day 5 blast and is frozen.

Post # 14
Member
278 posts
Helper bee
  • Wedding: July 2014

DH and I were “explained” as MFI (low morphology) and chose to go straight to IVF even though we were counseled to try IUIs first. I am so glad we did. As it turns out, I have severe egg quality issues, something we would not have found out about without IVF. All of my tests were great – great egg supply, uterus & tubes normal, ovulating on my own, etc. The one thing that cannot be determined without actually seeing the eggs is egg quality, and I am just unlucky in that regard. I am honestly so grateful for the MFI diagnosis – I’m pretty sure we’d still be langushing in the “unexplained” category otherwise, spending time and money on IUIs that had no chance of working while my eggs continued to deteriorate. We only got one embryo from our first IVF cycle, but I’m currently 9w3d pregnant with it 🙂 My advice is to go for the IVF. It’s extreme and not particularly pleasant, but you may learn something important in the process. My guess is that lots of “unexplained” infertility has to do with egg quality. More importantly, it will give you your best shot getting that BFP. Best of luck to you!

Post # 15
Member
219 posts
Helper bee
  • Wedding: July 2011

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yellowtulip8:  I am currently on day 8 of stims for my first IVF cycle so I can update with what will hopefully be a positive outcome in a few weeks! We too are totally unexplained and have been trying for 2 years. We did 3 IUIs with injectibles and I had great response, husbands numbers all great with absolutely nothing. It is hard to take the leap into IVF when nothing seems wrong but we wanted to do something with a better chance of success. My doctor says they can often see where the issue lies once you do IVF and can see what’s really going on. I also heard that 15-20% of couples who are unexplained have some type of fertilization issues and during IVF if they do not do ICSI end up with zero fertilized embryos. One thing that made me feel better about our decision was seeing the statistic on a website someone here posted which shares the percentage of pregnancy success after so many cycles based on your age (assuming you are reproductivly healthy). I put in my age and it gave a 99.9% chance of success after 24 cycles. So when you think about the fact that we are in the .1% of people who can’t get pregnant IVF doesn’t seem so extreme.

I would really recommend listening to the Beat Infetility podcast, especially the IVF 101 episode. it explained everything well and helped me understand more about the process. 

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