November infertility board

posted 1 year ago in TTC
Post # 421
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514 posts
Busy bee

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@itsme1987:  glad to hear it! FX for a good report!

Post # 422
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1401 posts
Bumble bee

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@electrichedgehog:  We reached a suspicion of autoimmune issues by ruling out other problems and some high antibody blood test results.

According to my doc, RPL (recurrent pregnancy loss) typically comes down to either

1: poor egg quality

2: structural abnormalities

3: autoimmune issues

She doesn’t think egg quality is the issue for me only due to my age (I just turned 31). But our embryos weren’t tested so it is a possibility. I did a carrier screening and I’m negative for everything, so we don’t suspect any type of genetic abnormality lurking in there.

We ruled out structrual abnormalities because my HSG, SHG, and hysteroscopy are all normal.

My thyroid antibodies were extremely high, as were my ANA and RNP antibodies (I didn’t know what those were until this). They’re often high in patients with diseases that I don’t have, like lupus, so I don’t have any clinical signs that anything is wrong. But the fact that I have three separate sky-high antibody tests points to my immune system being on overdrive. I also have celiac disease, which is an autoimmune disease. There are a couple of interventions that can help “calm down” the immune system a bit, which I’ll be doing when I transfer. It’s not a precise science, but I’m hoping it will help. 

Post # 423
Member
53 posts
Worker bee

@morecookiesplease:  It would be nice if the thyroid was “the thing” – it’s a little hard for me to believe that could be it for some reason!  We did all of the bloodwork they would need for the full workup (it was only one big draw for me – they didn’t bother with the day 3 tests after my second loss, I still don’t know why) plus an ultrasound.  It felt like she presented the HSG and hysteroscopy as options with relatively low odds of finding anything, which I think contributes to me just not feeling like we need to do that yet.  Maybe after more losses or a few more months of no luck I’ll feel differently.  I’ve had some other traumatic gyno procedures that were billed as NBD so I’m not in a hurry to try two more.

Post # 424
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53 posts
Worker bee

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@DogsAndWine:  Interesting!  All of my antibodies were negative, so that probably explains why it hasn’t come up.  My doctor also doesn’t think it’s egg quality since my count is high.  It is entirely possible we just got unlucky twice in a row.  The other thing she offered up was progresterone supplementation, though DH is hesitant about the risk of it prolonging a pregnancy that would have ended earlier.  We have a few weeks to decide, but I have the prescription on file in case we do want to try that with the next one.

Post # 425
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762 posts
Busy bee
  • Wedding: July 2012

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@electrichedgehog:  my clinic won’t pursue treatment without an hsg but since you already were pregnant it’s probably not going to reveal much. The hysteroscopy may be a better option since it would be able to check for polyps or fibroids. As a bonus I thought the hysteroscopy was not painful and I just had some very light cramping. But I don’t blame you for not doing it now unless there’s another reason to pursue it. 

Post # 426
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1144 posts
Bumble bee

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@DogsAndWine:  I hope the interventions are able to help calm down your immune system.  I’m sorry if you already explained and I forgot, but what sort of interventions do they recommend for you?  I have extremely high thyroid antibodies too but haven’t been tested for the others.  I want to start trying harder to work on improving my thyroid besides just the synthroid (which I am not sure really helps with antibodies anyways?). 

Post # 427
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1144 posts
Bumble bee

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@electrichedgehog:  that makes total sense!  All of the poking and prodding can get to be a lot so it’s understandable to want to take a break from that ❤️

Post # 428
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1401 posts
Bumble bee

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@morecookiesplease:  Currently I take a daily baby aspirin in addition to my synthroid and metformin. I’m going to take prednisone around my transfer as well as intralipid infusions. Some other interventions were mentioned, like neupogen, but I opted for these after doing some research into efficacy and cost. Even prednisone is only a “probable positive effect” but I’m willing to try! 

 

Post # 430
Member
635 posts
Busy bee
  • Wedding: September 2017

Well ultrasound #3 was frustrating as all hell. My little follicle is sitting at 10.7 on cd13. It barely grew 2 in 2 days which to my understanding doesnt look good. I was instructed to keep taking injections for 3 more days and go back on Tuesday for the decision to cancel or continue. I’ve decided this is the last round for gonal f though, I’m asking to go back to letrozole next IUI. I feel so defeated.

Post # 431
Member
4076 posts
Honey bee
  • Wedding: November 2019 - Canada

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@morecookiesplease:  Darn, sorry about your BFN bee!! I hope your thyroid levels out for you this month so you can figure out your game plan for your next cycle! <3

Post # 432
Member
514 posts
Busy bee

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@mrsnitti17:  don’t feel defeated, the thing I’ve learned with IVF is it’s a disaster until it works. Each round brings you closer. 

Post # 433
Member
635 posts
Busy bee
  • Wedding: September 2017

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@jen9999:  thanks for the encouraging words, it can just be so frustrating.

I took an OPK this morning and of course it was positive which meant I needed to go in for US and blood before expected. My little follicle grew to 15.7 so now I have to make the decision to still follow through with the IUI with a possibly immature egg or cancel this cycle and save the cost for next round. I’m so conflicted and seriously dont know what to do.

Post # 434
Member
514 posts
Busy bee

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@mrsnitti17:  in my experience iui has a somewhat low chance of success. I definitely recommend moving to IVF if you’ve done a few unsuccessful rounds of iui. As far as this round goes, can you remind me I recall you only need to get over 18mm right? What are your concerns that this egg won’t meet the threshold?

Post # 435
Member
635 posts
Busy bee
  • Wedding: September 2017

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@jen9999:  this is IUI #2 for us. Last one failed with a 17. You should be at 18 but time of trigger. That said I am ovulating on my own at 15.7 so theres no stopping it now, I will be ovulating below the usual for sure.

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