Recurrent Miscarriage – test results

posted 4 weeks ago in TTC
Post # 2
Member
263 posts
Helper bee
  • Wedding: July 2013

No, but I am sorry you are struggling with this. I wish you the best in the future.

Post # 3
Member
618 posts
Busy bee

nameless :  

So I don’t have any personal experience, but I used to perform these tests when I was a biomedical scientist. I think based on what you’ve written your doctor is looking for an antiphospholipid syndrome such as lupus anticoagulant, which is a disorder than can cause recurrent  miscarriages. 

Post # 5
Member
1449 posts
Bumble bee
  • Wedding: September 2015

So sorry for your loss.  My best friend is going through IF + RPL and of course pregnancy loss is always hard (I had one miscarriage but thankfully only one) but repeated loss is its own different kind of hell.

One thing I will say is Make sure the doctors don’t just test you!

Sperm provides half of the DNA yet it’s woefully overlooked by REs. Plus the placenta is made by the dad’s DNA and placental abnormalities can certainly lead to miscarriage.

Semen analysis does NOT tell you the whole story. My best friend who, after experiencing this personally, has done a lot of research into sperm DNA fragmentation. What she found from reading literally hundreds of research articles is that this is not gonna show up in a SA. Because the sperm may look OK on the outside, but the DNA packet inside the sperm head is damaged. So even if it manages to fertilize an egg, the DNA that sperm contains is basically like a computer program that’s missing pieces of code.

If not too much is missing (everybody has a certain level of damage because ain’t nobody perfect, but the average is about 8%, higher than that then the higher you go the more likely you’re gonna have problems). If not too much is missing then the egg can “repair” the damage by guessing what goes between the lines basically. But if the gaps are too wide then the egg can’t read between the lines anymore. If the missing code is something insignificant like oh you’re gonna have some acne then so be it. If the missing code is something like how to grow heart muscles then obviously there’s going to be a problem. Miscarriage and pregnancy loss due to DNA fragmentation can occur at any stage, so just because sperm can get somebody pregnant does NOT mean the problem is not with the sperm.

However most REs still don’t believe this and idk why. Sperm is literally 50% of the DNA so it boggles my mind that people would think it doesn’t matter and it’s all on the woman.  You may have to go to a Reproductive Urologist to take this seriously. My best friend who has personally experienced male factor infertility due to high sperm DNA fragmentation has done a TON of research. She has been advocating for other women and has brought a lot of awareness to this issue. Check out her extensive research on r/dnafragmentation.

Post # 6
Member
380 posts
Helper bee
  • Wedding: January 2016

No experience. I’m sorry you’re going through this though. Glad there was something abnormal to explain what’s going on and I do hope it is an easy fix. I had three losses in a row earlier this year and it’s the pits! No good at all. I do like what a previous poster mentioned about getting your husband checked out. If you’re going through all that effort yourself, might as well make sure there aren’t any additional factors contributing to what’s going on. While it’s probably not too likely, might as well be 100% thorough while you’re at it.

Post # 7
Member
4776 posts
Honey bee
  • Wedding: September 2015

camenae :  This is interesting.  My husband is on anxiety meds, and he recently switched…. we had horrible issues getting pregnant the first time, and he was off and on different meds for the 9 cycles we were trying.  He just switched to Effexor, and I briefly read that this was a possibility in sperm DNA from the Effexor.  There were a few antecdotes online about recurring miscarriages in women with partners on Effexor, but no real evidence.  We want to start TTC again this coming year, and I’m a bit worried.  I’ve asked my husband to get on a fertility supplement.

Post # 8
Member
4776 posts
Honey bee
  • Wedding: September 2015

nameless :  I have no real experience with this, but I’m so sorry you’re going through this.  I hope the doctor and tests can find out what the problem is so you can get the situation under control and get your rainbow baby soon <3  Thinking of you!

Post # 10
Member
618 posts
Busy bee

nameless :  

Yeah they are definitely looking lupus (SLE) then. The good news is in terms of pregnancy the treatment to prevent miscarriages is quite simple, usually it is just aspirin. The problem with lupus is you form blood clots too easily, and the clots can cause miscarriages. If you have had recurrent miscarriages they may also give you heparin injections. The heparin and aspirin work by reducing the ability of your blood to clot, thereby preventing miscarriages and other complications. 

I used to do the blood tests for lupus and monitor the heparin levels in pregnant ladies, so if you have any questions please let me know. 

Post # 12
Member
618 posts
Busy bee

nameless :  

Definitely mention it to your doctor, I’m not an expert on immunology, my area was coagulation and blood disorders so I’m not sure if kidney disease would cause false positives in the tests you’ve had. There is another test for lupus called lupus anticoagulant (aPTT & dRVVT), which as far as I know is not affected by kidney disease (check with your doctor though as I’m not 100%), which may be useful. 

Post # 14
Member
369 posts
Helper bee
  • Wedding: February 2017 - City, State

nameless :  what are your cycles like? Length/pain/ovulation etc.

I got pregnant with my first 2 easily but had to make major changes with the last 2. I also have an autoimmune disease. 

3 miscarriages in a row to me point towards progesterone or autoimmune. Your cycle could tell more. Do you have any other symptoms that you suffer from? Gastrointestinal, joint pain etc.?

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