Post # 1
Those of you with unexplained infertility, primary or secondary, what finally worked for you? Did anything? I am *this* close to giving up and I either need to hear how there’s hope – or I need a firm dose of reality and need to hear that it’s ok to stop.
Background – daughter was conceived the first month we tried, no effort involved. Have been trying almost 2 years for #2 and nothing. Every test is normal for both husband and myself.
-Normal 27/28 day cycles, have always clearly ovulated on my own without medicine (blazing positive opk every month)
-O is usually CD 15, 11-12 day LP
-Progesterone generally in mid 20s on 7DPO blood draw
-Have been on Clomid for last three months, switching to letrozole this month
-HSG = clear
-Have been temping for over a year, use preseed, no alcohol, limited caffeine
ETA: We cannot afford IVF so that will not be an option. We could do IUI but I have heard it isn’t really any more successful than just timed intercourse..?
Post # 2
I’m so sorry you’re dealing with this! I’m not dealing with infertility but I do have Hashimoto’s and it seems to me your TSH is higher than ideal for TTC and pregnancy purposes. Did they do an extended bloodtest to check if you have any thyroid issues? Did your doctor say anything about it? You’d want your TSH staying between 1 and 2 according to my doctor.
Post # 3
I asked both my OB, and eventually my RE when I switched to him and they both said under 2.5 is ok so they weren’t worried about 2.52 *shrugs*. I’ve defintiely read otherwise like you said, but what do I do if neither doctor wants to investigate further?
Post # 4
agree with dutchmrstobee :
it’s the only thing my GP, obgyn and RE have agreed on that the tsh should be 1-2
Post # 5
ugh it sucks that they refuse to do something with it. Is it a possibility to switch doctors or get a 2nd (or 3rd) opinion on it?
Post # 6
We are unexplained for our first, we just did our third IUI. Doctors have said it isn’t much more successful than just timed intercourse, but it’s the only thing we have insurance coverage for so we figured we’d try a few rounds
Post # 7
We had UI with our first and our second took 6 months to conceive.
we used a supplement called proxeed which was recommended to us by our infertility doctor. With both babies we conceived on the 4th month of both of us taking it. The packs say to use for 4 months or until pregnant so it might have helped my hubby’s swimmers 🤷🏼♀️ It’s not cheap though.
with both pregnancies just before I got pregnant I’d reached the point of resignation. With my first I’d accepted the need for IVF and I found out I was pregnant 4 days before our first cycle. With my second id accepted that my son would be my only child. No idea if that had anything to do with it though.
Post # 8
Agree with others to press more on the Thyroid stuff.
As for IUI, this isn’t my story, but a friend with secondary infertility did one round of clomid and then one clomid + IUI and on the IUI ended up pregnant with fraternal twins (which is a little terrifying on its own, but shows that both the clomid and the IUI worked…).
Post # 9
We had unexplained infertility. Everything was normal for both if us and I had very regular cycles.
We did 3 IUIs and I got pregnant on the last. After 3 years of trying, i feel like the IUI must have helped…
Post # 10
Unexplained secondary infertility here. Conceived our first right away. Had trouble with our second. Tests were mostly normal (my progesterone was low and husband’s morphology wasn’t great – but all docs said these were technically within normal range). Got pregnant once on Letrozole and timed intercourse but lost the baby. Doubled my Letrozole, added trigger shot and IUI, and successfully conceived our daughter (this was our 4th overall medicated round). Anecdotal, but IUI can work!
Post # 11
hug to you, love. No answers (still waiting for a first baby that sticks) but I’m in similar space emotionally and ready to think about ending the ttc crazy. I have no diagnosis as yet but all tests have been totally normal though I haven’t done the hsg (or in my case they want a saline sono) but I’m expecting it will be clear too. We’re doing drastic changes to our diet (no alcohol or caffiene, very low sugar, nothing processed, no dairy, no unrefined carbs, a lot of medicinal soups made by Taiwanese DH) and avoiding all plastics to eliminate bpa. No idea if it will work, it feels like true desperation. We already eat so healthfully it’s hard to think this could be what’s missing but we can’t afford (financially or relationally) ivf so I’ll try it. I want answers for us both! This is so tough. Here if you ever want to vent.
Post # 12
I would definitely seek a third opinion re: that high TsH.
I also have an third-person anecdote for you. My good friend was trying for over a year. She finally got pregnant a few months afte she she started exercising and added coq10 and vitamin d supplements. CoQ10 is supposed to help with egg quality, while vitamin D is linked to higher implantation rates. Have you read It Starts with an Egg? It’s a quick and interesting read and could offer some hope.
Post # 13
any complications with the delivery of your first child? Your description of your cycles and prior fertility makes me wonder whether your uterine cavity needs to be evaluated more thoroughly (by saline sono or hysteroscopy- HSG is not sufficient). I (sort of) had primary infertility (diagnosed with POI, tried IVF unsuccessfully, conceived while waiting to start IVF #2). We are now trying for #2 but recognize that we may not have success with my eggs since my ovaries/eggs are now 2 years older.
ETA: I’ve recently reviewed the literature on TSH and fertility treatment. The goal is TSH<2.5 so you are pretty close. Can you optimize taking your synthroid a little more? Do you take it on an empty stomach and wait a full hour? If you don’t, that will probably get you under 2.5.
Post # 14
I know the stats for IUI aren’t the best but anecdotally, it worked for me *and* two of my best friends… One friend on her 1st try, one friend on her 2nd try and me on my third. ETA: Also, about 5 of the 42 moms in my due date group had gotten pregnant with IUI.
Post # 15
Anacdotal here too. Got pregnant with my son (at 37) on the first month trying. Tried for #2 for a little over a year – during that time I had 2 chemicals and was put on levothyroxine for slightly elevated TSH. Tired lots of unmedicated timed intercourse, all unsucessful, and got pregnant on my third IUI (at 39) – I did have a trigger shot but no medication aside from that. Sending you loads of hugs as I know after the chemicals and failed IUIs, I was starting to panic and insanely confused as to why it was so easy with my first and then just. not. happening.